Peripheral and central-type benzodiazepine binding sites in mammalian ocular tissues

Both the mammalian and avian retina contain benzodiazepine-binding sites which resemble those in the central nervous system. These sites: are localized on neuronal membranes; have high affinity for centrally-active benzodiazepines like clonazepam, flunitrazepam and diazepam; have very low affinity f...

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Veröffentlicht in:	Experimental eye research 1984, Vol.38 (1), p.101-104
1. Verfasser:	Hirsch, James D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals benzodiazepines Benzodiazepines - metabolism Benzodiazepinones - metabolism Binding Sites Biological and medical sciences eye Eye - metabolism Eye and associated structures. Visual pathways and centers. Vision Female Flumazenil Flunitrazepam - metabolism Fundamental and applied biological sciences. Psychology Macaca mulatta Male Mammalia Rabbits Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs
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Zusammenfassung:	Both the mammalian and avian retina contain benzodiazepine-binding sites which resemble those in the central nervous system. These sites: are localized on neuronal membranes; have high affinity for centrally-active benzodiazepines like clonazepam, flunitrazepam and diazepam; have very low affinity for the non-anxiolytic benzodiazepine, Ro5-4864; and are regulated by gamma -aminobutyric acid (GABA) and other modulators.
ISSN:	0014-4835 1096-0007
DOI:	10.1016/0014-4835(84)90144-1