Effects of retinoic acid on rat bone

The effects of retinoic acid on rat bones were investigated. Fifteen adult male Sprague-Dawley rats were given various oral doses of retinoic acid (0–20 mg/kg body weight/day, 5 days/wk) and were killed after various treatment periods (1–17 wk). Histological and microradiographic examination of the...

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Veröffentlicht in:	Food and chemical toxicology 1984-01, Vol.22 (3), p.199-206
Hauptverfasser:	Dhem, A., Goret-Nicaise, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone and Bones - drug effects Bone Resorption - drug effects Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Radiography Rats Rats, Inbred Strains Tibia - diagnostic imaging Tibia - drug effects Tibia - pathology Tretinoin - pharmacology vitamin A
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Zusammenfassung:	The effects of retinoic acid on rat bones were investigated. Fifteen adult male Sprague-Dawley rats were given various oral doses of retinoic acid (0–20 mg/kg body weight/day, 5 days/wk) and were killed after various treatment periods (1–17 wk). Histological and microradiographic examination of the bones showed the presence of lesions, the development of which was dependent on the dose and the duration of treatment. These lesions were characterized by a dissolution of bone matrix, leaving only fibrils, by osteocytic osteolysis and by an increase in osteoclastic resorption.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/0278-6915(84)90127-3