Depression of biliary glutathione excretion by chronic ethanol feeding in the rat

The effects of chronic alcohol feeding on biliary glutathione excretion were studied in rats pair fed diets containing either ethanol (36% of total energy) or isocaloric carbodydrate for 4–6 weeks. An exteriorized biliary-duodenal fistula was established and total glutathione (GSH) and oxidized glut...

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Veröffentlicht in:	Life Sci.; (United States) 1984-03, Vol.34 (11), p.1065-1073
Hauptverfasser:	Vendemiale, Gianluigi, Jayatilleke, Elizabeth, Shaw, Spencer, Lieber, Charles S.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) Alcoholism and acute alcohol poisoning ALCOHOLS AMINO ACIDS ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Bile - drug effects BILIARY TRACT Biliary Tract - drug effects BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY CARBOXYLIC ACIDS CHRONIC INTAKE CLEARANCE DAYS LIVING RADIOISOTOPES DIET DIGESTIVE SYSTEM DOSE-RESPONSE RELATIONSHIPS DRUGS ETHANOL Ethanol - pharmacology EVEN-ODD NUCLEI EXCRETION GLANDS GLUTATHIONE Glutathione - metabolism HYDROXY COMPOUNDS INHIBITION INTAKE ISOTOPE APPLICATIONS ISOTOPES KINETICS LIGHT NUCLEI LIPOTROPIC FACTORS LIVER Male MAMMALS Medical sciences METHIONINE Methionine - metabolism NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS ORGANS Oxidation-Reduction PEPTIDES POLYPEPTIDES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOPROTECTIVE SUBSTANCES RATS Rats, Inbred Strains REACTION KINETICS RODENTS SULFUR 35 SULFUR ISOTOPES TOXICITY Toxicology TRACER TECHNIQUES VERTEBRATES
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Zusammenfassung:	The effects of chronic alcohol feeding on biliary glutathione excretion were studied in rats pair fed diets containing either ethanol (36% of total energy) or isocaloric carbodydrate for 4–6 weeks. An exteriorized biliary-duodenal fistula was established and total glutathione (GSH) and oxidized glutathione (GSSG) were measured. A significant decrease was observed in rats fed alcohol chronically compared to their pair fed controls in the biliary excretion of GSH (55.7±37.0 vs 243.1±29.0 μg/ml bile, p
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(84)90020-1