Lipoprotein Lipase Activities in Heart Muscle of Streptozotocin-Induced Diabetic Rats

Summary Triglyceride lipase (TGL) activities in the homogenates of the rat heart muscle were studied. TGL activity per mg protein of heart muscle was the highest in heart muscle homogenate utilizing 2.1 M glycine buffer, pH 8.3 among the assays investigated. The effects of NaCl, serum and heparin on...

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Veröffentlicht in:	Hormone and metabolic research 1984-02, Vol.16 (2), p.67-70
Hauptverfasser:	Nakai, T., Oida, K., Tamai, T., Yamada, S., Kobayashi, T., Hayashi, T., Kutsumi, Y., Takeda, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - analysis Cholesterol - blood Diabetes Mellitus, Experimental - enzymology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Lipase - metabolism Male Medical sciences Myocardium - enzymology Rats Rats, Inbred Strains Triglycerides - blood
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Zusammenfassung:	Summary Triglyceride lipase (TGL) activities in the homogenates of the rat heart muscle were studied. TGL activity per mg protein of heart muscle was the highest in heart muscle homogenate utilizing 2.1 M glycine buffer, pH 8.3 among the assays investigated. The effects of NaCl, serum and heparin on TGL activities in heart muscle homogenates indicated the characteristics of lipoprotein lipase (LPL). Twelve-hour fasting increased heart muscle LPL activity, while enzyme activities in 48 hour- and 72 hour-fasted rats were lower than those in fed rats. LPL activities in heart muscle homogenates in streptozotocin (STZ)-induced diabetic rats either 3 days or 4 weeks after STZ injection, were decreased significantly as compared with those of control rats.
ISSN:	0018-5043 1439-4286
DOI:	10.1055/s-2007-1014699