The Importance of the K1 Capsule in Invasive Infections Caused by Escherichia coli
We examined 534 clinical isolates of Escherichia coli for sensitivity to rough lipopolysaccharide-specific and K1-specific phages. Twenty-eight percent of bacteremic isolates were sensitive to rough-specific phages. Forty-two percent of these strains, against only 20% of bacteremic isolates insensit...
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| Veröffentlicht in: | The Journal of infectious diseases 1984-02, Vol.149 (2), p.184-193 |
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| creator | Cross, Alan S. Gemski, Peter Sadoff, Jerald C. Ørskov, Frits Ørskov, Ida |
| description | We examined 534 clinical isolates of Escherichia coli for sensitivity to rough lipopolysaccharide-specific and K1-specific phages. Twenty-eight percent of bacteremic isolates were sensitive to rough-specific phages. Forty-two percent of these strains, against only 20% of bacteremic isolates insensitive to rough-specific phages, had K1 capsule (P |
| doi_str_mv | 10.1093/infdis/149.2.184 |
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Twenty-eight percent of bacteremic isolates were sensitive to rough-specific phages. Forty-two percent of these strains, against only 20% of bacteremic isolates insensitive to rough-specific phages, had K1 capsule (P <0.001). K1-positive strains were usually resistant to phagocytic killing, whereas strains lacking the K1 capsule were more likely to be killed regardless of capsular type. Eighty-two percent of strains were typable with O-specific, 57% with K-specific, and 74% with H-specific antisera. Sixty percent of E coli were agglutinated by only 10 O-specific antisera. K1 was the most common capsular type, followed by K5, K2, and K12, whereas four H antigens accounted for nearly half of the H-typable strains. We conclude that (1) the combination of rough-specific and K1-specific phage sensitivity defines functionally similar groups of bacteria and (2) a polyvalent vaccine against invasive E coli is possible given the relatively limited number of invasive O:K:H serotypes.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/149.2.184</identifier><identifier>PMID: 6199436</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Antigens ; Antigens, Bacterial - analysis ; Bacteria ; Bacterial Capsules ; Bacteriology ; Bacteriophage Typing ; Bacteriophages ; Biological and medical sciences ; Blood ; Blood Bactericidal Activity ; Capsules ; Cerebrospinal Fluid - microbiology ; Child ; Child, Preschool ; Electrophoresis, Polyacrylamide Gel ; Escherichia coli ; Escherichia coli - classification ; Escherichia coli Infections - microbiology ; Feces - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Infant, Newborn ; Infections ; Lipopolysaccharides - analysis ; Male ; Microbiology ; Middle Aged ; Molecules ; O Antigens ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Phagocytosis ; Phenotypes ; Polysaccharides ; Polysaccharides, Bacterial - analysis ; Sepsis - microbiology ; Serotyping ; Urinary Tract Infections - microbiology ; Wounds and Injuries - microbiology</subject><ispartof>The Journal of infectious diseases, 1984-02, Vol.149 (2), p.184-193</ispartof><rights>Copyright 1984 The University of Chicago</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-fefcb7be923f50f017215b668e1e697d8486312f160be1d478848c58c13503fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30109706$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30109706$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9590856$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6199436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cross, Alan S.</creatorcontrib><creatorcontrib>Gemski, Peter</creatorcontrib><creatorcontrib>Sadoff, Jerald C.</creatorcontrib><creatorcontrib>Ørskov, Frits</creatorcontrib><creatorcontrib>Ørskov, Ida</creatorcontrib><title>The Importance of the K1 Capsule in Invasive Infections Caused by Escherichia coli</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>We examined 534 clinical isolates of Escherichia coli for sensitivity to rough lipopolysaccharide-specific and K1-specific phages. Twenty-eight percent of bacteremic isolates were sensitive to rough-specific phages. Forty-two percent of these strains, against only 20% of bacteremic isolates insensitive to rough-specific phages, had K1 capsule (P <0.001). K1-positive strains were usually resistant to phagocytic killing, whereas strains lacking the K1 capsule were more likely to be killed regardless of capsular type. Eighty-two percent of strains were typable with O-specific, 57% with K-specific, and 74% with H-specific antisera. Sixty percent of E coli were agglutinated by only 10 O-specific antisera. K1 was the most common capsular type, followed by K5, K2, and K12, whereas four H antigens accounted for nearly half of the H-typable strains. We conclude that (1) the combination of rough-specific and K1-specific phage sensitivity defines functionally similar groups of bacteria and (2) a polyvalent vaccine against invasive E coli is possible given the relatively limited number of invasive O:K:H serotypes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Antigens, Bacterial - analysis</subject><subject>Bacteria</subject><subject>Bacterial Capsules</subject><subject>Bacteriology</subject><subject>Bacteriophage Typing</subject><subject>Bacteriophages</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Bactericidal Activity</subject><subject>Capsules</subject><subject>Cerebrospinal Fluid - microbiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Escherichia coli</subject><subject>Escherichia coli - classification</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Lipopolysaccharides - analysis</subject><subject>Male</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Molecules</subject><subject>O Antigens</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Phagocytosis</subject><subject>Phenotypes</subject><subject>Polysaccharides</subject><subject>Polysaccharides, Bacterial - analysis</subject><subject>Sepsis - microbiology</subject><subject>Serotyping</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Wounds and Injuries - microbiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9rFDEYhoNY6tp69yLkIN5mmy-_c5S12sXSQqkgXkImk7CpszNrMlPsf2_KruvRU8L3vN_7wYPQWyBLIIZdpCF2qVwAN0u6BM1foAUIphopgb1EC0IobUAb8wq9LuWBEMKZVKfoVIIx9btAd_ebgNfb3ZgnN_iAx4inOvkKeOV2Ze4DTgNeD4-upMcaHGLwUxqHUvFcQofbJ3xZ_Cbk5DfJYT_26RydRNeX8ObwnqFvny_vV1fN9e2X9erjdeM58KmJIfpWtcFQFgWJBBQF0UqpAwRpVKe5lgxoBEnaAB1Xuk680B6YICw6doY-7Ht3efw1hzLZbSo-9L0bwjgXq4nRnBn4bxCY5pQxWoNkH_R5LCWHaHc5bV1-skDss2-7922rb0tt9V1X3h2653YbuuPCQXDl7w_cFe_6mKvlWvA3ZoQhWsh_NQ9lGvMRM1KvKvLMmz1PZQq_j9zln1YqpoS9-v7DfhKK3skbZTn7AyjEoFk</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Cross, Alan S.</creator><creator>Gemski, Peter</creator><creator>Sadoff, Jerald C.</creator><creator>Ørskov, Frits</creator><creator>Ørskov, Ida</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198402</creationdate><title>The Importance of the K1 Capsule in Invasive Infections Caused by Escherichia coli</title><author>Cross, Alan S. ; Gemski, Peter ; Sadoff, Jerald C. ; Ørskov, Frits ; Ørskov, Ida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-fefcb7be923f50f017215b668e1e697d8486312f160be1d478848c58c13503fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Antigens, Bacterial - analysis</topic><topic>Bacteria</topic><topic>Bacterial Capsules</topic><topic>Bacteriology</topic><topic>Bacteriophage Typing</topic><topic>Bacteriophages</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Bactericidal Activity</topic><topic>Capsules</topic><topic>Cerebrospinal Fluid - microbiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Escherichia coli</topic><topic>Escherichia coli - classification</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Lipopolysaccharides - analysis</topic><topic>Male</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Molecules</topic><topic>O Antigens</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Phagocytosis</topic><topic>Phenotypes</topic><topic>Polysaccharides</topic><topic>Polysaccharides, Bacterial - analysis</topic><topic>Sepsis - microbiology</topic><topic>Serotyping</topic><topic>Urinary Tract Infections - microbiology</topic><topic>Wounds and Injuries - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cross, Alan S.</creatorcontrib><creatorcontrib>Gemski, Peter</creatorcontrib><creatorcontrib>Sadoff, Jerald C.</creatorcontrib><creatorcontrib>Ørskov, Frits</creatorcontrib><creatorcontrib>Ørskov, Ida</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cross, Alan S.</au><au>Gemski, Peter</au><au>Sadoff, Jerald C.</au><au>Ørskov, Frits</au><au>Ørskov, Ida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Importance of the K1 Capsule in Invasive Infections Caused by Escherichia coli</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1984-02</date><risdate>1984</risdate><volume>149</volume><issue>2</issue><spage>184</spage><epage>193</epage><pages>184-193</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We examined 534 clinical isolates of Escherichia coli for sensitivity to rough lipopolysaccharide-specific and K1-specific phages. Twenty-eight percent of bacteremic isolates were sensitive to rough-specific phages. Forty-two percent of these strains, against only 20% of bacteremic isolates insensitive to rough-specific phages, had K1 capsule (P <0.001). K1-positive strains were usually resistant to phagocytic killing, whereas strains lacking the K1 capsule were more likely to be killed regardless of capsular type. Eighty-two percent of strains were typable with O-specific, 57% with K-specific, and 74% with H-specific antisera. Sixty percent of E coli were agglutinated by only 10 O-specific antisera. K1 was the most common capsular type, followed by K5, K2, and K12, whereas four H antigens accounted for nearly half of the H-typable strains. We conclude that (1) the combination of rough-specific and K1-specific phage sensitivity defines functionally similar groups of bacteria and (2) a polyvalent vaccine against invasive E coli is possible given the relatively limited number of invasive O:K:H serotypes.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>6199436</pmid><doi>10.1093/infdis/149.2.184</doi><tpages>10</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1984-02, Vol.149 (2), p.184-193 |
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| subjects | Adolescent Adult Aged Antigens Antigens, Bacterial - analysis Bacteria Bacterial Capsules Bacteriology Bacteriophage Typing Bacteriophages Biological and medical sciences Blood Blood Bactericidal Activity Capsules Cerebrospinal Fluid - microbiology Child Child, Preschool Electrophoresis, Polyacrylamide Gel Escherichia coli Escherichia coli - classification Escherichia coli Infections - microbiology Feces - microbiology Female Fundamental and applied biological sciences. Psychology Humans Infant Infant, Newborn Infections Lipopolysaccharides - analysis Male Microbiology Middle Aged Molecules O Antigens Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phagocytosis Phenotypes Polysaccharides Polysaccharides, Bacterial - analysis Sepsis - microbiology Serotyping Urinary Tract Infections - microbiology Wounds and Injuries - microbiology |
| title | The Importance of the K1 Capsule in Invasive Infections Caused by Escherichia coli |
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