Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T-cell lymphoma and several T-cell hybridomas. These characteristics suggest that it encodes o...

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Veröffentlicht in:Nature (London) 1984-03, Vol.308 (5955), p.149-153
Hauptverfasser: Hedrick, Stephen M, Cohen, David I, Nielsen, Ellen A, Davis, Mark M
Format: Artikel
Sprache:eng
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Zusammenfassung:Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T-cell lymphoma and several T-cell hybridomas. These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes.
ISSN:0028-0836
1476-4687
DOI:10.1038/308149a0