Mutants of Bacteriophage T4 Defective in the Induction of T4 Endonuclease II

Mutants of Bacteriophage T4 Defective in the Induction of T4 Endonuclease II

Some mutants of bacteriophage T4 selected for their inability to replicate in the presence of hydroxyurea are defective in the degradation of host DNA. Nine such mutants which all map in the same locus (the "denA" locus) were all deficient in the induction of T4 endonuclease II. We conclud...

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Veröffentlicht in:The Journal of biological chemistry 1971-05, Vol.246 (10), p.3431-3433
Hauptverfasser: Sadowski, Paul D., Warner, Huber R., Hercules, Kitty, Munro, Judith L., Mendelsohn, Steven, Wiberg, John S.
Format: Artikel
Sprache:eng
Schlagworte:
Chromatography
Chromosome Mapping
Coliphages - enzymology
Deoxyribonucleases - biosynthesis
DNA, Bacterial
Enzyme Induction
Escherichia coli
Hydroxyurea
Mutation
Virus Replication
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Zusammenfassung:Some mutants of bacteriophage T4 selected for their inability to replicate in the presence of hydroxyurea are defective in the degradation of host DNA. Nine such mutants which all map in the same locus (the "denA" locus) were all deficient in the induction of T4 endonuclease II. We conclude that this enzyme is involved in the breakdown of cellular DNA.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)62242-2