Long-term inhibition of ovulation by a GnRH-antagonist at low dose level

Ac-D-Trp 1,3, D-Cpa 2, D-Lys 6, D-Ala 10-GnRH ∗∗ ∗∗ Cpa refers to 4-chloro-phenylalanine. has been prepared by solid phase synthesis. The peptide was found to completely inhibit ovulation when administered on proestrus day in a dose of 1.5 μg/rat, s.c. The peptide completely inhibited ovulation for...

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Veröffentlicht in:	Biochemical and biophysical research communications 1984-01, Vol.118 (1), p.351-355
Hauptverfasser:	Kovacs, Magdolna, Mezo, Imre, Flerko, Bela, Teplan, Istvan, Nikolics, Karoly
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay Drug Administration Schedule Female Gonadotropin-Releasing Hormone - administration & dosage Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - chemical synthesis Gonadotropin-Releasing Hormone - pharmacology Indicators and Reagents Ovulation - drug effects Pregnancy Proestrus - drug effects Rats
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Beschreibung
Zusammenfassung:	Ac-D-Trp 1,3, D-Cpa 2, D-Lys 6, D-Ala 10-GnRH ∗∗ ∗∗ Cpa refers to 4-chloro-phenylalanine. has been prepared by solid phase synthesis. The peptide was found to completely inhibit ovulation when administered on proestrus day in a dose of 1.5 μg/rat, s.c. The peptide completely inhibited ovulation for a period corresponding to three to four cycles when administered daily in a dose of 5 μg/rat, s.c. and caused 70% inhibition of ovulation in a dose of 3 μg/rat.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(84)91108-2