Ionic regulation of cyclic AMP levels in Paramecium tetraurelia in vivo

cAMP levels in Paramecium increased dose dependently after a step increase of [Ca] or [Sr] in the incubation, provided K was present. Two mM Ca or Sr tripled cAMP concentrations within 3 s and induced an increase in forward swimming speed. The increase in cAMP formation was strictly dependent on the...

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Veröffentlicht in:	FEBS letters 1984-02, Vol.167 (1), p.113-116
Hauptverfasser:	Schultz, Joachim E., Grünemund, Ruth, von Hirschhausen, Reginhard, Schönefeld, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Animals Biological and medical sciences Calcium Calcium - pharmacology Cell metabolism, cell oxidation Cell physiology Cyclic AMP Cyclic AMP - metabolism Excitable membrane Fundamental and applied biological sciences. Psychology membrane potential Models, Biological Molecular and cellular biology Movement - drug effects Paramecium Paramecium - metabolism Paramecium tetraurelia Potassium - metabolism Strontium - pharmacology Time Factors
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Zusammenfassung:	cAMP levels in Paramecium increased dose dependently after a step increase of [Ca] or [Sr] in the incubation, provided K was present. Two mM Ca or Sr tripled cAMP concentrations within 3 s and induced an increase in forward swimming speed. The increase in cAMP formation was strictly dependent on the Donnan ratio ▪ Na, Li, or tetraethylammonium could not replace K. The data provide evidence for regulation of cAMP in Paramecium by the membrane surface charge as determined specifically by the K:Ca ratio.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(84)80843-1