Up-regulation of brain [ 3H]diazepam binding sites in chronic caffeine-treated rats
Brain [ 3H]diazepam and l-[ 3H]phenylisopropyladenosine binding sites in caffeine-treated (75 mg/kg/day, i.p. 12 days) and caffeine-withdrawn (30 days) rats were examined. Treatment with caffeine (75 mg/kg/day) for 12 days increases the B max (maximum binding capacity) for [ 3H]diazepam binding by 3...
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Veröffentlicht in: | Brain research 1984-02, Vol.294 (1), p.186-189 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Brain [
3H]diazepam and
l-[
3H]phenylisopropyladenosine binding sites in caffeine-treated (75 mg/kg/day, i.p. 12 days) and caffeine-withdrawn (30 days) rats were examined. Treatment with caffeine (75 mg/kg/day) for 12 days increases the B
max (maximum binding capacity) for [
3H]diazepam binding by 30.9% whereas the same treatment increased the B
max for
l-[
3H]PIA binding by 120%. The B
max for [
3H]diazepam binding sites returns to slightly below control levels but
l-[
3H]PIA binding sites still remain elevated after 30 days of caffeine withdrawal. The up-regulation of [
3H]diazepam binding sites seen in caffeine-treated rats may indicate an interaction between caffeine and benzodiazepines at the receptor level and it may account for the supersensitivity to benzodiazepines seen in behavioral testing. |
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ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/0006-8993(84)91329-5 |