Up-regulation of brain [ 3H]diazepam binding sites in chronic caffeine-treated rats

Brain [ 3H]diazepam and l-[ 3H]phenylisopropyladenosine binding sites in caffeine-treated (75 mg/kg/day, i.p. 12 days) and caffeine-withdrawn (30 days) rats were examined. Treatment with caffeine (75 mg/kg/day) for 12 days increases the B max (maximum binding capacity) for [ 3H]diazepam binding by 3...

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Veröffentlicht in:Brain research 1984-02, Vol.294 (1), p.186-189
Hauptverfasser: Wu, P.H., Coffin, V.L.
Format: Artikel
Sprache:eng
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Zusammenfassung:Brain [ 3H]diazepam and l-[ 3H]phenylisopropyladenosine binding sites in caffeine-treated (75 mg/kg/day, i.p. 12 days) and caffeine-withdrawn (30 days) rats were examined. Treatment with caffeine (75 mg/kg/day) for 12 days increases the B max (maximum binding capacity) for [ 3H]diazepam binding by 30.9% whereas the same treatment increased the B max for l-[ 3H]PIA binding by 120%. The B max for [ 3H]diazepam binding sites returns to slightly below control levels but l-[ 3H]PIA binding sites still remain elevated after 30 days of caffeine withdrawal. The up-regulation of [ 3H]diazepam binding sites seen in caffeine-treated rats may indicate an interaction between caffeine and benzodiazepines at the receptor level and it may account for the supersensitivity to benzodiazepines seen in behavioral testing.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(84)91329-5