Male-restricted expression of H-Y antigen on preimplantation mouse embryos

The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to...

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Veröffentlicht in:	Transplantation 1984, Vol.37 (1), p.7-8
Hauptverfasser:	SHELTON, J. A, GOLDBERG, E. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blastocyst - immunology Complement System Proteins Embryo Transfer Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genetics of the immune response H-Y Antigen - genetics H-Y Antigen - immunology Immune Sera - pharmacology Immunobiology Male Mice Mice, Inbred A Mice, Inbred C57BL Sex Differentiation
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Zusammenfassung:	The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indicates that the H-Y-bearing embryos are male.
ISSN:	0041-1337 1534-6080
DOI:	10.1097/00007890-198401000-00004