Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis

The downstream (3′) long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5′) LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1984, Vol.307 (5948), p.241-245
Hauptverfasser:	Cullen, B.R, Lomedico, P.T, Ju, G
Format:	Artikel
Sprache:	eng
Schlagworte:	animal diseases animal health Animals avian leukosis virus Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Transformation, Viral Chickens Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humanities and Social Sciences Insulin - genetics Leukemia, Experimental - genetics Leukemia, Experimental - microbiology Molecular and cellular biology multidisciplinary Mutation Oncogenes Operon Repetitive Sequences, Nucleic Acid Retroviridae - genetics Science Science (multidisciplinary) Transcription, Genetic viral diseases of animals and humans Viral Envelope Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The downstream (3′) long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5′) LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c- myc in avian leukosis virus induced lymphomas of chickens.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/307241a0