Low-Molecular-Weight Substance in Peritoneal Exudate Is Antibacterial at Febrile Temperature
Abstract Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1984-02, Vol.175 (2), p.233-236 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 175 |
| creator | Scales, Wendy E. Kluger, Matthew J. |
| description | Abstract
Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for rabbits) as compared with 39°C (afebrile temperature), suggesting the presence of an antibacterial agent active at febrile temperature. Further studies indicated that this antibacterial substance has a molecular weight less than 5000 Da. Heat treatment (70°C, 1 hr) had no influence upon the activity of the inhibitory factor. |
| doi_str_mv | 10.3181/00379727-175-41794 |
| format | Article |
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Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for rabbits) as compared with 39°C (afebrile temperature), suggesting the presence of an antibacterial agent active at febrile temperature. Further studies indicated that this antibacterial substance has a molecular weight less than 5000 Da. Heat treatment (70°C, 1 hr) had no influence upon the activity of the inhibitory factor.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-175-41794</identifier><identifier>PMID: 6694978</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Ascitic Fluid ; Biological and medical sciences ; Crustacea ; Fever ; General aspects ; Glycogen - pharmacology ; Hot Temperature ; Infection pathogenesis ; Infectious diseases ; Leukocytes - physiology ; Male ; Medical sciences ; Molecular Weight ; Pasteurella - drug effects ; Pasteurella - growth & development ; Pasteurella multocida ; Rabbits</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1984-02, Vol.175 (2), p.233-236</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9581270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6694978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scales, Wendy E.</creatorcontrib><creatorcontrib>Kluger, Matthew J.</creatorcontrib><title>Low-Molecular-Weight Substance in Peritoneal Exudate Is Antibacterial at Febrile Temperature</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for rabbits) as compared with 39°C (afebrile temperature), suggesting the presence of an antibacterial agent active at febrile temperature. Further studies indicated that this antibacterial substance has a molecular weight less than 5000 Da. Heat treatment (70°C, 1 hr) had no influence upon the activity of the inhibitory factor.</description><subject>Animals</subject><subject>Ascitic Fluid</subject><subject>Biological and medical sciences</subject><subject>Crustacea</subject><subject>Fever</subject><subject>General aspects</subject><subject>Glycogen - pharmacology</subject><subject>Hot Temperature</subject><subject>Infection pathogenesis</subject><subject>Infectious diseases</subject><subject>Leukocytes - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Weight</subject><subject>Pasteurella - drug effects</subject><subject>Pasteurella - growth & development</subject><subject>Pasteurella multocida</subject><subject>Rabbits</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78AUHoQbxFk6ZpkqOIHwsrCq54EcI0TrXSbdckRf33Zt3Vo56G4X1mhnkI2efsWHDNTxgTyqhcUa4kLbgyxRoZcSkkFaUx62S0AOiC2CLbIbwyxqXKy02yWZamMEqPyOOkf6fXfYtuaMHTB2yeX2J2N1QhQucwa7rsFn0T-w6hzc4_hieImI1DdtrFpgIXU5gCiNkFVr5pMZvibI4e4uBxl2zU0AbcW9Udcn9xPj27opOby_HZ6YQ6UZhIZS2hMA4AnEEm0fG61BXD1JSVyl0uUMv0CtROOoFKaGMENwnSujSqEDvkaLl37vu3AUO0syY4bFvosB-C1cwUUjH1L8iFzjmTOoH5EnS-D8Fjbee-mYH_tJzZhXv7494m9_bbfRo6WG0fqhk-_Y6sZKf8cJVDcNDWPhluwi9mpOa5Ygk7WWIBntG-9oPvkry_Dn8BB9iZSg</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Scales, Wendy E.</creator><creator>Kluger, Matthew J.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198402</creationdate><title>Low-Molecular-Weight Substance in Peritoneal Exudate Is Antibacterial at Febrile Temperature</title><author>Scales, Wendy E. ; Kluger, Matthew J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-5f5a49caaac9e05ec1f68b0e9e06b72c23e85003afc5c3e73899319f688869743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Ascitic Fluid</topic><topic>Biological and medical sciences</topic><topic>Crustacea</topic><topic>Fever</topic><topic>General aspects</topic><topic>Glycogen - pharmacology</topic><topic>Hot Temperature</topic><topic>Infection pathogenesis</topic><topic>Infectious diseases</topic><topic>Leukocytes - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Weight</topic><topic>Pasteurella - drug effects</topic><topic>Pasteurella - growth & development</topic><topic>Pasteurella multocida</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scales, Wendy E.</creatorcontrib><creatorcontrib>Kluger, Matthew J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scales, Wendy E.</au><au>Kluger, Matthew J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-Molecular-Weight Substance in Peritoneal Exudate Is Antibacterial at Febrile Temperature</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1984-02</date><risdate>1984</risdate><volume>175</volume><issue>2</issue><spage>233</spage><epage>236</epage><pages>233-236</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for rabbits) as compared with 39°C (afebrile temperature), suggesting the presence of an antibacterial agent active at febrile temperature. Further studies indicated that this antibacterial substance has a molecular weight less than 5000 Da. Heat treatment (70°C, 1 hr) had no influence upon the activity of the inhibitory factor.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>6694978</pmid><doi>10.3181/00379727-175-41794</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1984-02, Vol.175 (2), p.233-236 |
| issn | 0037-9727 1535-3702 1535-3699 1525-1373 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Ascitic Fluid Biological and medical sciences Crustacea Fever General aspects Glycogen - pharmacology Hot Temperature Infection pathogenesis Infectious diseases Leukocytes - physiology Male Medical sciences Molecular Weight Pasteurella - drug effects Pasteurella - growth & development Pasteurella multocida Rabbits |
| title | Low-Molecular-Weight Substance in Peritoneal Exudate Is Antibacterial at Febrile Temperature |
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