Low-Molecular-Weight Substance in Peritoneal Exudate Is Antibacterial at Febrile Temperature

Abstract Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1984-02, Vol.175 (2), p.233-236
Hauptverfasser:	Scales, Wendy E., Kluger, Matthew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascitic Fluid Biological and medical sciences Crustacea Fever General aspects Glycogen - pharmacology Hot Temperature Infection pathogenesis Infectious diseases Leukocytes - physiology Male Medical sciences Molecular Weight Pasteurella - drug effects Pasteurella - growth & development Pasteurella multocida Rabbits
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Peritoneal exudate was collected from rabbits 18 hr after ip injection of shellfish glycogen. The fluid was centrifuged and the peritoneal exudate supernatant (PES) retained for use in growth studies. The growth of Pasteurella multocida in PES was inhibited at 41°C (febrile temperature for rabbits) as compared with 39°C (afebrile temperature), suggesting the presence of an antibacterial agent active at febrile temperature. Further studies indicated that this antibacterial substance has a molecular weight less than 5000 Da. Heat treatment (70°C, 1 hr) had no influence upon the activity of the inhibitory factor.
ISSN:	0037-9727 1535-3702 1535-3699 1525-1373
DOI:	10.3181/00379727-175-41794