Remarks on the Structure–Activity Relationship of Silver Sulfanilamides

□ The biological activity of a series of 10 silver sulfanilamides is studied in relation to the physical parameters pKa, log K, and the aqueous solubility. None of the parameters demonstrate a simple relationship with the activity. A discussion of the significance of log K and the solubility in rela...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1984-01, Vol.73 (1), p.133-135
Hauptverfasser:	Bult, A., Bajema, B.L., Boelema, G.J., Saene, J.J.M.V., Doornbos, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	and solubility Biological and medical sciences correlation between activity and pKa General pharmacology log K Medical sciences Ointments - analysis Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Pseudomonas aeruginosa - drug effects Silver Silver sulfanilamides-structure-activity relationships Silver sulfanilamides—structure-activity relationships, correlation between activity and pKa, log K, and solubility Structure-Activity Relationship Structure-activity relationships-silver sulfanilamides Structure-activity relationships—silver sulfanilamides, correlation between activity and pKa, log K, and solubility Sulfanilamides - pharmacology
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Beschreibung
Zusammenfassung:	□ The biological activity of a series of 10 silver sulfanilamides is studied in relation to the physical parameters pKa, log K, and the aqueous solubility. None of the parameters demonstrate a simple relationship with the activity. A discussion of the significance of log K and the solubility in relation to the activity is given.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600730138