Identification and Linkage Analyses of a Gene, Rcs-1, Suppressing Spontaneous SJL/J Lymphoma Expression

Identification and Linkage Analyses of a Gene, Rcs-1, Suppressing Spontaneous SJL/J Lymphoma Expression

Populations of SJL/J (SJL), A.SW/SnJ (A.SW), F1, and backcross mice were followed over 2 years for the spontaneous development of reticulum cell sarcoma (RCS). A.SW, F1, and SJL mice demonstrated cumulative RCS incidences of 0, 9, and greater than 95%, respectively. The incidence of RCS in SJL × (SJ...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1984-02, Vol.72 (2), p.441-446
1. Verfasser: BUBBERS, J. E
Format: Artikel
Sprache:eng
Schlagworte:
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Female
Gene Expression Regulation
Genetic Linkage
Genetic Markers
Lymphoma, Large B-Cell, Diffuse - genetics
Male
Medical sciences
Mice
Mice, Inbred Strains
Spontaneous animal tumors
Suppression, Genetic
Tumors
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Zusammenfassung:Populations of SJL/J (SJL), A.SW/SnJ (A.SW), F1, and backcross mice were followed over 2 years for the spontaneous development of reticulum cell sarcoma (RCS). A.SW, F1, and SJL mice demonstrated cumulative RCS incidences of 0, 9, and greater than 95%, respectively. The incidence of RCS in SJL × (SJL × A.SW), SJL × (A.SW × SJL), and (SJL × A.SW) × SJL backcross mice was 58%, a rate consistent (P
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/72.2.441