The Dog as a Quantitative Model for Evaluation of Nondisintegrating Sustained-Release Tablets

Beagle dogs were evaluated as a possible model for the preliminary evaluation of nondisintegrating sustained-release tablets. A quantitative comparison of the rate and extent of absorption of the drug from sustained- and nonsustained-release dosage forms in man and dog was obtained. The data suggest...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1971-01, Vol.60 (1), p.132-134
Hauptverfasser:	Cressman, William A., Sumner, Darrell
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Absorption, sustained-, nonsustained-release dosage forms—rate, extent studied in man, dog, comparison Animals Appetite Depressants - blood Carbon Isotopes compared comparison Delayed-Action Preparations Dog Dog, quantitative model—nondisintegrating sustained-release tablet evaluation Dogs extent of absorption-studied extent studied in man Intestinal Absorption Male man Mathematics Models, Biological nonsustained-release dosage form nonsustained-release dosage forms-rate Oxazoles - blood quantitative model-nondisintegrating sustained-release tablet evaluation rate Sustained Sustained-, nonsustained-release dosage form, rate, extent of absorption—studied, compared, man, dog Tablets Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Beagle dogs were evaluated as a possible model for the preliminary evaluation of nondisintegrating sustained-release tablets. A quantitative comparison of the rate and extent of absorption of the drug from sustained- and nonsustained-release dosage forms in man and dog was obtained. The data suggest that the dog is a satisfactory model to screen dosage forms for possible human testing. The specific limitations of the model are discussed.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600600130