Entropic Factor in the Solubility of Small Particles

A mechanistic basis for the dependence of solubility on particle size was investigated. The solubility difference between a crystalline and microcrystalline solid was determined; the microcrystalline solid had a greater solubility than the crystalline. The heat of solution, as determined from a Van&...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1971-01, Vol.60 (1), p.130-131
Hauptverfasser:	Smolen, Victor F., Kildsig, Dane O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Phenomena Chemistry crystalline Entropic factor-small particle solubility Griseofulvin Griseofulvin, crystalline, microcrystalline—Van't Hoff plot of relative solubilities Mathematics microcrystalline-Van't Hoff plot of relative solubilities Particle size-solubility dependence Solubility Temperature
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Beschreibung
Zusammenfassung:	A mechanistic basis for the dependence of solubility on particle size was investigated. The solubility difference between a crystalline and microcrystalline solid was determined; the microcrystalline solid had a greater solubility than the crystalline. The heat of solution, as determined from a Van't Hoff plot, was found to be independent of particle size. The observed solubility difference was interpreted to be due to a relatively greater entropy of solution for the microcrystalline solid as compared to the crystalline solid.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600600129