Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease: Evidence for the Dependence of Renal Function on Prostacyclin

We investigated whether the glomerular synthesis of prostacyclin modulates the renal blood flow and glomerular filtration rate in chronic glomerular disease. The urinary excretion of 6-keto-prostaglandin F 1α , a stable breakdown product of prostacyclin, was significantly (P

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 1984-02, Vol.310 (5), p.279-283
Hauptverfasser:	Ciabattoni, Giovanni, Cinotti, Giulio A, Pierucci, Alessandro, Simonetti, Bianca M, Manzi, Massimo, Pugliese, Francesco, Barsotti, Paola, Pecci, Gabriella, Taggi, Franco, Patrono, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - urine Adolescent Adult Aged Biological and medical sciences Blood flow Blood platelets Chronic Disease Creatinine Creatinine - metabolism Dinoprostone Drug dosages Epoprostenol - biosynthesis Epoprostenol - physiology Excretion Female Glomerular Filtration Rate Glomerulonephritis - drug therapy Glomerulonephritis - physiopathology Humans Ibuprofen Ibuprofen - pharmacology Ibuprofen - therapeutic use Indenes - pharmacology Kidney - physiopathology Kidney Glomerulus - metabolism Laboratory animals Lupus Medical sciences Metabolites Middle Aged Nonsteroidal anti-inflammatory drugs p-Aminohippuric Acid - blood Patients Pharmacology Pharmacology. Drug treatments Prostacyclin Prostaglandin E2 Prostaglandin endoperoxide synthase Prostaglandins E - urine Proteins Renal Circulation Renal function Substance abuse treatment Sulindac Sulindac - pharmacology Sulindac - therapeutic use Urinary system Urine Womens health
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Beschreibung
Zusammenfassung:	We investigated whether the glomerular synthesis of prostacyclin modulates the renal blood flow and glomerular filtration rate in chronic glomerular disease. The urinary excretion of 6-keto-prostaglandin F 1α , a stable breakdown product of prostacyclin, was significantly (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198402023100502