Cholesterogenesis and related enzymes in isolated rat hepatocytes during pre- and postnatal life
Cholesterogenesis pathway during pre‐ and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3‐hydroxy‐3‐methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 114C...
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| Veröffentlicht in: | Journal of cellular physiology 1984-01, Vol.118 (1), p.62-66 |
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| container_title | Journal of cellular physiology |
| container_volume | 118 |
| creator | Leoni, S. Spagnuolo, S. Conti-Devirgiliis, L. Dini, L. Mangiantini, M. T. Trentalance, A. |
| description | Cholesterogenesis pathway during pre‐ and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3‐hydroxy‐3‐methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 114C‐acetate incorporation into cholesterol and HMGCoA reductase activity were present at 16 days of fetal development in newborn and suckling rats, whereas both parameters increased rapidly before birth. The pattern of NaF nonsuppressible reductase activity showed a different activation state of the enzyme, suggesting the appearance of a modulation state, probably related to the development of some short‐term regulatory mechanisms. |
| doi_str_mv | 10.1002/jcp.1041180112 |
| format | Article |
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The pattern of NaF nonsuppressible reductase activity showed a different activation state of the enzyme, suggesting the appearance of a modulation state, probably related to the development of some short‐term regulatory mechanisms.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.1041180112</identifier><identifier>PMID: 6140267</identifier><identifier>CODEN: JCLLAX</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acetates - metabolism ; Animals ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Cells, Cultured ; Cholesterol - biosynthesis ; Female ; Fetus - metabolism ; Fundamental and applied biological sciences. 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T.</creatorcontrib><creatorcontrib>Trentalance, A.</creatorcontrib><title>Cholesterogenesis and related enzymes in isolated rat hepatocytes during pre- and postnatal life</title><title>Journal of cellular physiology</title><addtitle>J. Cell. Physiol</addtitle><description>Cholesterogenesis pathway during pre‐ and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3‐hydroxy‐3‐methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 114C‐acetate incorporation into cholesterol and HMGCoA reductase activity were present at 16 days of fetal development in newborn and suckling rats, whereas both parameters increased rapidly before birth. The pattern of NaF nonsuppressible reductase activity showed a different activation state of the enzyme, suggesting the appearance of a modulation state, probably related to the development of some short‐term regulatory mechanisms.</description><subject>Acetates - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>Cholesterol - biosynthesis</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxymethylglutaryl CoA Reductases - analysis</subject><subject>Hydroxymethylglutaryl-CoA Synthase - analysis</subject><subject>Liver - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Sodium Fluoride - pharmacology</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAUha2KCoZpt90hZYHYZfAjceJlNTA8hFoqTdWle-PcgKknCXZGMPx6DBlN1VVXtny-c-x7TMgXRmeMUn76YPq4yRgrKWP8A5kwqoo0kznfI5MIsFTlGTsghyE8UEqVEmKf7EuWUS6LCfk9v-8chgF9d4ctBhsSaOvEo4MB6wTbl80KQ2LbxIZuPPMwJPfYw9CZzRC1eu1te5f0HtN3b9-FoYUBXOJsg5_IxwZcwM_bdUp-Ls6X88v05vvF1fzrTWoE5zytoMlKyHkNDedSCQRhciErU5Vl1bAyKw2TWS6wyCmWhYLKCKwKKVHVIAoppuRkzO1997iOE-mVDQadgxa7ddAlVXFg-QbORtD4LgSPje69XYHfaEb1W6U6Vqr_VhoNR9vkdbXCeodvO4z68VaHYMA1Hlpjww5TEaEqj5gasSfrcPOfS_X1_PafJ6Sj18afet55wf_RMb3I9a9vF3rxg53dLulSM_EK_BSfTg</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Leoni, S.</creator><creator>Spagnuolo, S.</creator><creator>Conti-Devirgiliis, L.</creator><creator>Dini, L.</creator><creator>Mangiantini, M. 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T. ; Trentalance, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3222-baf48a52daf22693ea3c536bcb88bf1848c16453e750e879abc3eb766e9da3763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acetates - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>Cholesterol - biosynthesis</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydroxymethylglutaryl CoA Reductases - analysis</topic><topic>Hydroxymethylglutaryl-CoA Synthase - analysis</topic><topic>Liver - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Sodium Fluoride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leoni, S.</creatorcontrib><creatorcontrib>Spagnuolo, S.</creatorcontrib><creatorcontrib>Conti-Devirgiliis, L.</creatorcontrib><creatorcontrib>Dini, L.</creatorcontrib><creatorcontrib>Mangiantini, M. 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Physiol</addtitle><date>1984-01</date><risdate>1984</risdate><volume>118</volume><issue>1</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><coden>JCLLAX</coden><abstract>Cholesterogenesis pathway during pre‐ and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3‐hydroxy‐3‐methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 114C‐acetate incorporation into cholesterol and HMGCoA reductase activity were present at 16 days of fetal development in newborn and suckling rats, whereas both parameters increased rapidly before birth. The pattern of NaF nonsuppressible reductase activity showed a different activation state of the enzyme, suggesting the appearance of a modulation state, probably related to the development of some short‐term regulatory mechanisms.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6140267</pmid><doi>10.1002/jcp.1041180112</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9541 |
| ispartof | Journal of cellular physiology, 1984-01, Vol.118 (1), p.62-66 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Acetates - metabolism Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells, Cultured Cholesterol - biosynthesis Female Fetus - metabolism Fundamental and applied biological sciences. Psychology Hydroxymethylglutaryl CoA Reductases - analysis Hydroxymethylglutaryl-CoA Synthase - analysis Liver - metabolism Molecular and cellular biology Pregnancy Rats Sodium Fluoride - pharmacology |
| title | Cholesterogenesis and related enzymes in isolated rat hepatocytes during pre- and postnatal life |
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