Cholesterogenesis and related enzymes in isolated rat hepatocytes during pre- and postnatal life

Cholesterogenesis pathway during pre‐ and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3‐hydroxy‐3‐methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 114C...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of cellular physiology 1984-01, Vol.118 (1), p.62-66
Hauptverfasser: Leoni, S., Spagnuolo, S., Conti-Devirgiliis, L., Dini, L., Mangiantini, M. T., Trentalance, A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cholesterogenesis pathway during pre‐ and postnatal development was studied in isolated rat hepatocytes. No modified activity of cytosol acetoacetyl coenzyme A (CoA), thiolase, or 3‐hydroxy‐3‐methylglutaryl CoA (HMGCoA) synthase was detectable at the different stages examined. Minimal levels of 114C‐acetate incorporation into cholesterol and HMGCoA reductase activity were present at 16 days of fetal development in newborn and suckling rats, whereas both parameters increased rapidly before birth. The pattern of NaF nonsuppressible reductase activity showed a different activation state of the enzyme, suggesting the appearance of a modulation state, probably related to the development of some short‐term regulatory mechanisms.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.1041180112