The Human Homologs of the raf (mil) Oncogene are Located on Human Chromosomes 3 and 4

Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a process...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1984-01, Vol.223 (4631), p.71-74
Hauptverfasser:	Bonner, Tom, O'Brien, Stephen J., Nash, William G., Rapp, Ulf R., Morton, Cynthia C., Leder, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Animals Biological and medical sciences Cancer Cancer research Chromosome Aberrations Chromosome abnormalities Chromosome Mapping Chromosomes Chromosomes, Human, 1-3 Chromosomes, Human, 4-5 Cricetinae Cytogenetics DNA Fundamental and applied biological sciences. Psychology Genes Genes. Genome Genetic research Human chromosomes Humans Hybrid Cells Hybridity Kidney Neoplasms - genetics Lung Neoplasms - genetics Male Mice Molecular and cellular biology Molecular genetics Nucleic Acid Hybridization Oncogenes Oncology, Experimental Renal cell carcinoma Retroviridae Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6691137