Inhibition of Na Pumps Enhances Ca-dependent Release of Vasopressin from the Isolated Neurohypophysis of the Rat

The isolated neurohypophysis of the rat was incubated with a medium lacking Ca and vasopressin release was induced by reintroduction of Ca (2mM). The response to Ca was greatly enhanced after treatment with a medium containing ouabain or lacking K. The enhanced release of vasopressin by ouabain was...

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Veröffentlicht in:	Japanese journal of physiology 1983, Vol.33(6), pp.1061-1066
1. Verfasser:	SORIMACHI, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arginine-vasopressin Biological and medical sciences calcium Calcium - pharmacology Cobalt - pharmacology Fundamental and applied biological sciences. Psychology hormone release Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Male ouabain Ouabain - pharmacology pituitary (posterior) Pituitary Gland, Posterior - drug effects Pituitary Gland, Posterior - metabolism Potassium - pharmacology rat neurohypophysis Rats Rats, Inbred Strains sodium Sodium - metabolism Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors vasopressin Vasopressins - metabolism Vertebrates: endocrinology
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Zusammenfassung:	The isolated neurohypophysis of the rat was incubated with a medium lacking Ca and vasopressin release was induced by reintroduction of Ca (2mM). The response to Ca was greatly enhanced after treatment with a medium containing ouabain or lacking K. The enhanced release of vasopressin by ouabain was dependent on the concentration of external Na. The results suggest that inhibition of Na pumps leads to a rise in internal Na, thereby activating Na-dependent Ca influx mechanism associated with vasopressin release.
ISSN:	0021-521X 1881-1396
DOI:	10.2170/jjphysiol.33.1061