Peptides as channel-making ionophores: Conformational aspects

Peptides as channel-making ionophores: Conformational aspects

The β 62.4‐ and β 126.6‐helical structures do not appear consistent with the structural data and ion‐transport properties of (Ala‐Ala‐Gly) or (Leu‐Ser‐Leu‐Gly) oligomers. Oligoalanine derivatives also give rise to current fluctuations in bilayer lipid membranes. Bundles of molecules may explain the...

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Veröffentlicht in:Biopolymers 1983-01, Vol.22 (1), p.403-407
Hauptverfasser: Spach, Gérard, Trudelle, Yves, Heitz, Fréadéric
Format: Artikel
Sprache:eng
Schlagworte:
Ion Channels - metabolism
ions
lipid bilayers
Membrane Potentials
Membrane Proteins - metabolism
Models, Biological
Models, Molecular
peptides
Peptides - metabolism
Protein Conformation
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Zusammenfassung:The β 62.4‐ and β 126.6‐helical structures do not appear consistent with the structural data and ion‐transport properties of (Ala‐Ala‐Gly) or (Leu‐Ser‐Leu‐Gly) oligomers. Oligoalanine derivatives also give rise to current fluctuations in bilayer lipid membranes. Bundles of molecules may explain the behavior of these various peptides in membranes.
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.360220153