Metabolism of 17α-methyltestosterone in the rabbit: C-6 and C-16 hydroxylated metabolites

17α-Methyltestosterone and the reduced metabolites, 17α-methyl-5α-androstane-3α,17β-diol, 17α-methyl-5α-androstane-3α,17β-diol and 17α-methyl-5β-androstane-3α,17β-diol, together with three hydroxylated metabolites, 17α-methyl-5β-androstane-3α,16β,17β-triol, 17α-methyl-5β-androstane-3β,16α,17β-triol and a new metabolite, 17α-methyl-5α-androstane-3β,6α,17β-triol, were isolated and identified in the urine of rabbits dosed with 17α-methyltestosterone. No hydroxylated 5α-metabolite of 17α-methyltestosterone has been identified previously. No evidence for epimerization at the C-17 position was observed.