Specific inhibition of mitochondrial Ca ++ transport by ruthenium red
The ability of rat liver mitochondria to transport calcium ions has been found to be inhibited specifically by the dye ruthenium red. Since this dye reacts specifically with mucopolysaccharides, and since energy conservation is not inhibited by this dye, it is concluded that mucopolysaccharides (in...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1971-01, Vol.42 (2), p.298-305 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Moore, Cyril L. |
| description | The ability of rat liver mitochondria to transport calcium ions has been found to be inhibited specifically by the dye ruthenium red. Since this dye reacts specifically with mucopolysaccharides, and since energy conservation is not inhibited by this dye, it is concluded that mucopolysaccharides (in the form of mucoproteins or muco or glycolipids) are at the active center of the sites of mediation of mitochondrial Ca
++ transport. |
| doi_str_mv | 10.1016/0006-291X(71)90102-1 |
| format | Article |
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| ispartof | Biochemical and biophysical research communications, 1971-01, Vol.42 (2), p.298-305 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Binding Sites Biological Transport, Active Calcium - metabolism Coloring Agents - pharmacology Depression, Chemical Glycolipids - metabolism Glycosaminoglycans - metabolism In Vitro Techniques Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mucoproteins - metabolism Oxygen Consumption Quaternary Ammonium Compounds - pharmacology Rats Ruthenium - pharmacology |
| title | Specific inhibition of mitochondrial Ca ++ transport by ruthenium red |
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