Specific inhibition of mitochondrial Ca ++ transport by ruthenium red

Specific inhibition of mitochondrial Ca ++ transport by ruthenium red

The ability of rat liver mitochondria to transport calcium ions has been found to be inhibited specifically by the dye ruthenium red. Since this dye reacts specifically with mucopolysaccharides, and since energy conservation is not inhibited by this dye, it is concluded that mucopolysaccharides (in...

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Veröffentlicht in:Biochemical and biophysical research communications 1971-01, Vol.42 (2), p.298-305
1. Verfasser: Moore, Cyril L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites
Biological Transport, Active
Calcium - metabolism
Coloring Agents - pharmacology
Depression, Chemical
Glycolipids - metabolism
Glycosaminoglycans - metabolism
In Vitro Techniques
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Mucoproteins - metabolism
Oxygen Consumption
Quaternary Ammonium Compounds - pharmacology
Rats
Ruthenium - pharmacology
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Zusammenfassung:The ability of rat liver mitochondria to transport calcium ions has been found to be inhibited specifically by the dye ruthenium red. Since this dye reacts specifically with mucopolysaccharides, and since energy conservation is not inhibited by this dye, it is concluded that mucopolysaccharides (in the form of mucoproteins or muco or glycolipids) are at the active center of the sites of mediation of mitochondrial Ca ++ transport.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(71)90102-1