The appearance of an IgD-like molecule on pig lymphocytes during ontogeny

An IgD-like molecule was found on the surface of pig fetal lymphocytes using guinea pig anti-human IgD antisera and indirect immunofluorescence. The binding of antiIgD antisera could be specifically inhibited with human IgD. Surface IgD-like molecules were found later in ontogeny than surface IgM (a...

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Veröffentlicht in:	Folia microbiologica 1983-01, Vol.28 (6), p.484-488
Hauptverfasser:	TREBICHAVSKY, I, ZIKAN, J, TRAVNICEK, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - immunology Antibodies, immunoglobulins Biological and medical sciences Fetus - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Immunoglobulin D - analysis Immunoglobulin M - analysis Lymphocytes - immunology Molecular immunology Swine Swine, Miniature - embryology Swine, Miniature - immunology
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Zusammenfassung:	An IgD-like molecule was found on the surface of pig fetal lymphocytes using guinea pig anti-human IgD antisera and indirect immunofluorescence. The binding of antiIgD antisera could be specifically inhibited with human IgD. Surface IgD-like molecules were found later in ontogeny than surface IgM (after about 70 d of gestation in the spleen). There is evidence for their endogenous origin. The number of lymphocytes bearing IgD-like molecules rapidly increased during ontogeny.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02879687