Cancer: A simple metabolic disease?

Recent studies on the effects of the essential fatty acid metabolic intermediate, gamma-linolenic acid, on the growth of cancer cells in culture and on induced mammary cancer tumours in rats, strongly suggest that the metabolic defect in the cancer cells studied is simply a metabolic block involving...

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Veröffentlicht in:	Medical hypotheses 1983-11, Vol.12 (3), p.195-201
Hauptverfasser:	Booyens, J., Katzeff, I.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - metabolism Alprostadil Animals Cancer Carcinoma, Hepatocellular - metabolism Cell Line Cells, Cultured Delta-6-desaturase Esophageal Neoplasms - metabolism Fatty Acid Desaturases - metabolism Gamma-linolenic acid History of medicine Humans Linolenic Acids - metabolism Liver Neoplasms Melanoma - metabolism Metabolic disease Metabolic Diseases Mice Neoplasms - enzymology Neoplasms - etiology Neoplasms - metabolism Prostaglandin E 1 Prostaglandins E - biosynthesis Scurvy - etiology Scurvy - history
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Zusammenfassung:	Recent studies on the effects of the essential fatty acid metabolic intermediate, gamma-linolenic acid, on the growth of cancer cells in culture and on induced mammary cancer tumours in rats, strongly suggest that the metabolic defect in the cancer cells studied is simply a metabolic block involving the enzyme delta-6-desaturase. The latter enzyme is responsible for the conversion of linoleic acid to gamma-linolenic acid. These observations would suggest that cancer in the cell lines studied could be a relatively simple metabolic disease.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/0306-9877(83)90038-5