Aggregations of 35-Nanometer Particles Associated with Neuronal Cytopathic Changes in Natural Scrapie

Aggregations of 35-Nanometer Particles Associated with Neuronal Cytopathic Changes in Natural Scrapie

Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1971-01, Vol.171 (3969), p.389-390
Hauptverfasser: Bignami, A., Parry, H. B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Budding
Cytopathogenic Effect, Viral
Cytoplasm
Dehydrogenases
Glycolates
Glyoxylates
Hyperoxaluria
Hypothalamus - cytology
Lactates
Microscopy, Electron
Nervous system diseases
Neurons
Neurons - cytology
Oxalates
Scrapie - pathology
Sheep
Vacuoles
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Beschreibung
Zusammenfassung:Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the 35-nm particles are found in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. Such particles are present only in a small number of vacuolated neurons.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.171.3969.389