Treatment of urinary tract infections in gynecological patients: A randomized study comparing pivampicillin-pivmecillinam with trimethoprim-sulphamethoxazole

Eighty-two gynecological patients with clinical signs of a lower urinary tract infection (UTI) were randomized to 10 days' treatment with either a fixed combination of pivampicillin-pivmecillinam (PAPM) or trimethoprim-sulphamethoxazole (TMPS). The effect of treatment could be evaluated in 25 p...

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Veröffentlicht in:Acta obstetricia et gynecologica Scandinavica 1983, Vol.62 (5), p.515-518
Hauptverfasser: Iosif, Constantin S., Laurin, Jan, Möller, Eva-Brita, Bauer, Carl-Axel
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Sprache:eng
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Zusammenfassung:Eighty-two gynecological patients with clinical signs of a lower urinary tract infection (UTI) were randomized to 10 days' treatment with either a fixed combination of pivampicillin-pivmecillinam (PAPM) or trimethoprim-sulphamethoxazole (TMPS). The effect of treatment could be evaluated in 25 patients on PAPM and in 19 on TMPS, who had bacteriologically verified UTI and who completed treatment and check-ups. All strains were sensitive in vitro to the respective antibiotic combination used. Treatment eradicated the original pathogen in 75 - 80% of the cases, 64% of the patients on PAPM and 47% on TMPS having sterile urine 3 weeks after end of treatment. Side effects could be evaluated in 76 patients. Two patients on PAPM and 8 on TMPS had to discontinue treatment due to side effects. Including abnormal values for hematology, liver and renal parameters, significantly fewer side effects (p = 0.038) were noted on PAPM (7/40) than on TMPS (15/36).
ISSN:0001-6349
1600-0412
DOI:10.3109/00016348309154228