Sarcomerogenesis in human myocardium

Myocardial tissue obtained at the time of open heart surgery from 19 patients, rat ventricular cells grown in tissue culture and atrial and ventricular tissue from newborn puppies were examined with the electron microscope in order to delineate the function of the sarcomeric Z band. The data obtaine...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1970-12, Vol.1 (4), p.425,IN13,433-432,IN41,437
1. Verfasser:	Legato, Marianne J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomechanical Phenomena Culture Techniques Dogs Heart - growth & development Humans Microscopy, Electron Myocardium - cytology Myocardium - metabolism Myofibrils Rats
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Zusammenfassung:	Myocardial tissue obtained at the time of open heart surgery from 19 patients, rat ventricular cells grown in tissue culture and atrial and ventricular tissue from newborn puppies were examined with the electron microscope in order to delineate the function of the sarcomeric Z band. The data obtained from this investigation make it apparent that Z substance is essential for the production of new sarcomeres in the myofibril, and is the source of new contractile units in situations of growth, maintenance and repair in the heart.
ISSN:	0022-2828 1095-8584
DOI:	10.1016/0022-2828(70)90039-8