Transport of penicillamine across mucosa of the rat small intestine in vitro

Transport of d- and l-penicillamine against a concentration gradient was studied using everted sacs of rat small intestine. Uptake by segments of intestinal tissue was also studied. The l-isomer was actively transported but the d-isomer was not. Active transport of l-penicillamine was decreased in the presence of cyanide, l-methionine and l-valine. The effect of both penicillamine isomers on the transport of 35S- l-cysteine was also investigated.