Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II: Isolation and characterization

A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The isolation and characterization of three of...

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Veröffentlicht in:	Journal of antibiotics 1983-12, Vol.36 (12), p.1601-1605
Hauptverfasser:	STAMPWALA, S. S, BUNGE, R. H, HURLEY, T. R, WILLMER, N. E, BRANKIEWICZ, A. J, STEINMAN, C. E, SMITKA, T. A, FRENCH, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - isolation & purification Antibiotics, Antineoplastic - isolation & purification Antineoplastic agents Biological and medical sciences Chromatography, High Pressure Liquid Fermentation Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Polyenes Pyrones Spectrophotometry Streptomyces - growth & development Structure-Activity Relationship
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Zusammenfassung:	A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The isolation and characterization of three of these components are described.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.36.1601