mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products

Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular diversity 2010-08, Vol.14 (3), p.501-506
Hauptverfasser:	Liu, Nianjin, Cao, Song, Wu, Jingjing, Shen, Li, Yu, Jinlong, Zhang, Jian, Li, Hui, Qian, Xuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Chemistry, Organic - methods Dehydrofluorination Halogenation Lactams - chemical synthesis Lactams - chemistry Life Sciences Magnetic Resonance Spectroscopy Models, Chemical Monofluorinated α-lactam pseudopeptide Organic Chemistry Peptides - chemical synthesis Peptides - chemistry Pharmacy Polymer Sciences Short Communication Solvents - chemistry Ugi reaction
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Beschreibung
Zusammenfassung:	Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.
ISSN:	1381-1991 1573-501X
DOI:	10.1007/s11030-009-9209-x