Double-Blind Comparative Clinical Study of Cefpiramide (SM-1652) and Cefmetazole in Complicated Urinary Tract Infections

The clinical efficacy and safety of cefpiramide (SM-1652, CPM) were compared with those of cefmetazole (CMZ) in patients with complicated urinary tract infections by double-blind method. Either of CPM or CMZ was assigned to each patient at random. Administration was performed by intravenous drip infusion for a fixed period of 5 days and daily dosage was fixed at each 2 g for CPM or CMZ. Out of 249 patients, 211 patients (CPM; 110 cases, CMZ: 101 cases) were evaluated for clinical efficacy by the criteria proposed by UTI committee in Japan. It was indicated that there was no significant difference between the two groups (CPM group and CMZ group) regarding the all of background factors. Overall clinical effectiveness; Response was excellent in 27.7%, moderate in 39.8% and poor in 32.5% of the CPM group, excellent in 17.3%, moderate in 33.3% and poor in 49.3% of the CMZ group. Response rate inclusive of excellent and moderate was significantly higher in the CPM group than in the CMZ (p