Long-acting contraceptive agents: Norethisterone esters of arylcarboxylic acids

Long-acting contraceptive agents: Norethisterone esters of arylcarboxylic acids

The synthesis of esters of norethisterone (17α-ethynyl-17β-hydroxy-estr-4-en-3-one) with acids containing a benzene ring is described, two methods of esterification being compared in terms of yield and convenience. The activities of these esters as long-acting contraceptive agents have been evaluate...

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Veröffentlicht in:Steroids 1983-03, Vol.41 (3), p.309-320
Hauptverfasser: Wan, A.S.C., Ngiam, T.L., Leung, S.L., Go, M.L., Heng, P.W.S., Late) P.N. Natarajan, (The, Shafiee, A., Vossoghi, M., Savabi, F., Francisco, C.G., Freire, R., Hernandez, R., Salazar, J.A., Suarez, E., De La Mora, G.A.Garcia, R., Y.Grillasca, Jimeno, O.
Format: Artikel
Sprache:eng
Schlagworte:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Carboxylic Acids
Chemistry
Delayed-Action Preparations
Esters
Exact sciences and technology
Indicators and Reagents
Mass Spectrometry
Norethindrone - analogs & derivatives
Norethindrone - chemical synthesis
Organic chemistry
Population
Preparations and properties
Spectrophotometry, Infrared
Steroids
Structure-Activity Relationship
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Beschreibung
Zusammenfassung:The synthesis of esters of norethisterone (17α-ethynyl-17β-hydroxy-estr-4-en-3-one) with acids containing a benzene ring is described, two methods of esterification being compared in terms of yield and convenience. The activities of these esters as long-acting contraceptive agents have been evaluated.
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(83)90101-0