Elective tolerance to behavioral effects of neurotensin

Elective tolerance to behavioral effects of neurotensin

Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the...

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Veröffentlicht in:Physiology & behavior 1983-01, Vol.31 (4), p.467-470
Hauptverfasser: Rinkel, G.J.E., Hoeke, E.C., van Wimersma Greidanus, Tj.B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Biological and medical sciences
Drug Tolerance
Electroshock
Fundamental and applied biological sciences. Psychology
Locomotor activity
Male
Motor Activity - drug effects
Multimodal perception
Neurotensin
Neurotensin - pharmacology
Open field behavior
Perception
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Inbred Strains
Responsiveness to electric footshock
Tolerance
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Zusammenfassung:Neurotensin reduces locomotor activity in an open field situation as well as responsiveness to electric footshock. Repeated injections of neurotensin in combination with repeated testing of locomotor activity in the open field as well as repeated injections of neurotensin without such testing in the open field do not result in a reduction of locomotor activity. These findings make development of tolerance to this behavioral effect of neurotensin likely. Such a development of tolerance to neurotensin is not observed for the effect on responsiveness to electric footshock.
ISSN:0031-9384
1873-507X
DOI:10.1016/0031-9384(83)90067-7