Aging and cortisol resistance to suppression by dexamethasone: A positive correlation

Cortisol resistance to suppression by 0.5 mg of dexamethasone given at 11 p.m. was studied in 30 normal subjects, 17 to 78 years of age. Serum cortisol concentrations were determined by radioimmunoassay. A strong positive correlation was found between age and cortisol concentrations 9 hours after de...

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Veröffentlicht in:	Psychiatry research 1983-01, Vol.10 (2), p.125-130
Hauptverfasser:	Oxenkrug, Gregory F., Pomara, Nunzio, McIntyre, Iain M., Branconnier, Roland J., Stanley, Michael, Gershon, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aging Biological and medical sciences cortisol Dexamethasone Female Humans Hydrocortisone - blood Male Medical sciences Middle Aged Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radioimmunoassay Techniques and methods
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Zusammenfassung:	Cortisol resistance to suppression by 0.5 mg of dexamethasone given at 11 p.m. was studied in 30 normal subjects, 17 to 78 years of age. Serum cortisol concentrations were determined by radioimmunoassay. A strong positive correlation was found between age and cortisol concentrations 9 hours after dexamethasone administration. The data suggest that aging, per se, might contribute to the increased cortisol resistance to suppression by dexamethasone reported in depression and dementia.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/0165-1781(83)90111-7