Endotoxin‐induced in vitro release of interleukin‐1 by cancer patients' monocytes: Relation to stage of disease

The in vitro release of IL‐I by monocytcs in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL‐I release was low in patients with early cancer, no...

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Veröffentlicht in:	International journal of cancer 1983-12, Vol.32 (6), p.733-736
Hauptverfasser:	Pollack, Simon, Micali, Anita, Kinne, David W., Enker, Warren E., Geller, Nancy, Oettgen, Herbert F., Hoffmann, Michael K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Breast Neoplasms - immunology Breast Neoplasms - pathology Cell Division Cells, Cultured Colonic Neoplasms - immunology Colonic Neoplasms - pathology Endotoxins - pharmacology Female Host-tumor relations. Immunology. Biological markers Humans Interleukin-1 - immunology Male Medical sciences Melanoma - immunology Melanoma - pathology Mice Mice, Inbred C3H Middle Aged Monocytes - immunology Neoplasms - immunology Neoplasms - pathology Rectal Neoplasms - immunology Rectal Neoplasms - pathology Skin Neoplasms - immunology Skin Neoplasms - pathology T-Lymphocytes - cytology Tumors
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Zusammenfassung:	The in vitro release of IL‐I by monocytcs in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL‐I release was low in patients with early cancer, normal in patients with regional metastases, and low in patients with disseminated cancer.
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.2910320613