Decrease of lactoferrin concentration in the tears of myotonic muscular dystrophy patients

Decrease of lactoferrin concentration in the tears of myotonic muscular dystrophy patients

Tears from myotonic muscular dystrophy (MMD) patients and normal controls were analyzed for their tear proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Lactoferrin comprised about 18% of the total tear protein in MMD patients as opposed to about 27% in normals. The albumin cont...

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Veröffentlicht in:Clinica chimica acta 1983-01, Vol.134 (1), p.213-219
Hauptverfasser: Pi-Kwang, Tsung, Bor-Shyue, Hong, Holly, Frank J., Gordon, William
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Diseases of striated muscles. Neuromuscular diseases
Erythrocyte Membrane - analysis
Humans
Immunoelectrophoresis - methods
Lactoferrin - analysis
Lactoglobulins - analysis
Medical sciences
Muscular Dystrophies - metabolism
Neurology
Rosaniline Dyes
Tears - analysis
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Zusammenfassung:Tears from myotonic muscular dystrophy (MMD) patients and normal controls were analyzed for their tear proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Lactoferrin comprised about 18% of the total tear protein in MMD patients as opposed to about 27% in normals. The albumin content relative to total protein in MMD tears was about 25% while the same value for normals is 13%. The lactoferrin/albumin ratio, was about 0.8 for MMD patients and about 2.1 for normals.
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(83)90199-7