Role of PGE2 in the modulation of the adrenergic response in man

The influence of sympathetic stimulation (SS) (achieved by 2 min cold application) on the plasma concentration of PGE2, PGF2α (radioimmunoassay), noradrenaline (NA) and adrenaline (A) (radioenzymatic assay) and on forearm vascular resistance (indirect measurement, FVR) was studied in 16 healthy volu...

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Veröffentlicht in:	Cardiovascular research 1983-11, Vol.17 (11), p.662-670
Hauptverfasser:	SERNERI, GIAN G NERI, MASOTTI, G, CASTELLANI, S, SCARTI, L, TROTTA, F, MANNELLI, M
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenergic nervous system Adult Aspirin - analogs & derivatives Aspirin - pharmacology Biological and medical sciences catecholamines Cold Temperature Dinoprost Dinoprostone Epinephrine - blood Female Fundamental and applied biological sciences. Psychology Hemodynamics. Rheology Humans Indomethacin - pharmacology Lysine - analogs & derivatives Lysine - pharmacology Male Norepinephrine - blood PGE2 prostaglandins Prostaglandins E - blood Prostaglandins E - physiology Prostaglandins F - blood Sympathetic Nervous System - physiology sympathetic stimulation Vascular Resistance - drug effects Vertebrates: cardiovascular system
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Zusammenfassung:	The influence of sympathetic stimulation (SS) (achieved by 2 min cold application) on the plasma concentration of PGE2, PGF2α (radioimmunoassay), noradrenaline (NA) and adrenaline (A) (radioenzymatic assay) and on forearm vascular resistance (indirect measurement, FVR) was studied in 16 healthy volunteers before and after cyclooxygenase inhibition by indomethacin (200 mg per day orally for 3 days) and lysine acetylsalicylate (corresponding to 10 mg·kg−1 of acetylsalicylic acid -ASA- iv). SS induced a sharp increase in PGE2 (from 8.1 ±4.3 pg·ml−1 before SS to 23.9±6.5, P
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/17.11.662