Stabilization of serum albumin by anti-inflammatory drugs

Nonsteroidal anti-inflammatory agents inhibited the heat denaturation of serum albumin at drug levels betow 1 mM, as measured by turbidity and viscosity changes. The immunosuppressive, antihistamine, anticholinergic and antimalarial drugs tested did not show this property. Active drugs did not block...

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Veröffentlicht in:	Biochemical pharmacology 1970-03, Vol.19 (3), p.715-722
Hauptverfasser:	Grant, Norman H., Alburn, Harvey E., Kryzanauskas, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antimalarials - pharmacology Blood Viscosity Cattle Chemical Precipitation Collagen - metabolism Densitometry Detergents - pharmacology Fibrinogen - metabolism gamma-Globulins - metabolism Guanidines - pharmacology Histamine - pharmacology Histamine H1 Antagonists - pharmacology Hot Temperature Immunosuppressive Agents - pharmacology Indomethacin - pharmacology Ovalbumin - metabolism Oxyphenbutazone - pharmacology Parasympatholytics - pharmacology Phenylbutazone - pharmacology Protein Denaturation Salicylates - pharmacology Serum Albumin, Bovine - metabolism
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description	Nonsteroidal anti-inflammatory agents inhibited the heat denaturation of serum albumin at drug levels betow 1 mM, as measured by turbidity and viscosity changes. The immunosuppressive, antihistamine, anticholinergic and antimalarial drugs tested did not show this property. Active drugs did not block denaturation induced by alkali, detergents or guanidine, nor did they generally inhibit the denaturation of ovalbumin, fibrinogen, γ-globulin or collagen.
doi_str_mv	10.1016/0006-2952(70)90234-0
format	Article
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The immunosuppressive, antihistamine, anticholinergic and antimalarial drugs tested did not show this property. 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subjects	Animals Anti-Inflammatory Agents - pharmacology Antimalarials - pharmacology Blood Viscosity Cattle Chemical Precipitation Collagen - metabolism Densitometry Detergents - pharmacology Fibrinogen - metabolism gamma-Globulins - metabolism Guanidines - pharmacology Histamine - pharmacology Histamine H1 Antagonists - pharmacology Hot Temperature Immunosuppressive Agents - pharmacology Indomethacin - pharmacology Ovalbumin - metabolism Oxyphenbutazone - pharmacology Parasympatholytics - pharmacology Phenylbutazone - pharmacology Protein Denaturation Salicylates - pharmacology Serum Albumin, Bovine - metabolism
title	Stabilization of serum albumin by anti-inflammatory drugs
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