Accumulation of vancomycin after intraventricular infusions

A 50-year-old man with an infected intracerebral hematoma was treated with daily intraventricular infusions containing 10 mg of vancomycin (half the dose suggested by others). A vancomycin level in the ventricular CSF of 606 micrograms/ml after nine days of therapy indicates a potential for accumula...

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Veröffentlicht in:	Southern medical journal (Birmingham, Ala.) Ala.), 1983-12, Vol.76 (12), p.1554-1555
Hauptverfasser:	Arroyo, J C, Quindlen, E A
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Diseases - metabolism Humans Injections, Intraventricular Male Middle Aged Staphylococcal Infections - drug therapy Time Factors Vancomycin - administration & dosage Vancomycin - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A 50-year-old man with an infected intracerebral hematoma was treated with daily intraventricular infusions containing 10 mg of vancomycin (half the dose suggested by others). A vancomycin level in the ventricular CSF of 606 micrograms/ml after nine days of therapy indicates a potential for accumulation of this drug in patients with extensive brain damage.
ISSN:	0038-4348
DOI:	10.1097/00007611-198312000-00023