Complexes of Ergot Alkaloids and Derivatives V: Interaction of Methysergide Maleate and Caffeine in Aqueous Solution

Evidence of complex formation between methysergide maleate and caffeine is presented, utilizing solubility and vapor pressure osmometer information. The effect of this interaction on the rate of dissolution and partitioning-rate behavior of methysergide maleate has been measured. The absorption cons...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1970-12, Vol.59 (12), p.1836-1837
Hauptverfasser:	Zoglio, M.A., Maulding, H.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Caffeine caffeine complexes-interactions in aqueous solutions Chemical Phenomena Chemistry derivatives-complexes effect on dissolution Ergot alkaloids Ergot alkaloids, derivatives—complexes, methysergide, caffeine methysergide Methysergide maleate Methysergide maleate, caffeine complexes—interactions in aqueous solutions, effect on dissolution, partition rates partition rates Vapor pressure osmometry-complex formation data Vapor pressure osmometry—complex formation data, methysergide maleate, caffeine
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Beschreibung
Zusammenfassung:	Evidence of complex formation between methysergide maleate and caffeine is presented, utilizing solubility and vapor pressure osmometer information. The effect of this interaction on the rate of dissolution and partitioning-rate behavior of methysergide maleate has been measured. The absorption consequences of this interaction as implied from the in vitro studies are presented.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600591229