A polymorphic DNA marker genetically linked to Huntington's disease

Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this d...

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Veröffentlicht in:	Nature (London) 1983-11, Vol.306 (5940), p.234-238
Hauptverfasser:	Gusella, James F., Wexler, Nancy S., Conneally, P. Michael, Naylor, Susan L., Anderson, Mary Anne, Tanzi, Rudolph E., Watkins, Paul C., Ottina, Kathleen, Wallace, Margaret R., Sakaguchi, Alan Y., Young, Anne B., Shoulson, Ira, Bonilla, Ernesto, Martin, Joseph B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Mapping Chromosomes, Human, 4-5 Cloning, Molecular DNA Restriction Enzymes Female Genetic Linkage Humanities and Social Sciences Humans Huntington Disease - diagnosis Huntington Disease - genetics Male multidisciplinary Pedigree Polymorphism, Genetic Science Science (multidisciplinary)
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Beschreibung
Zusammenfassung:	Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/306234a0