SITES OF ANALGESIC ACTION OF CIRAMADOL

Antinociceptive effects of ciramadol were evaluated using three analgesic tests: the tail-pinch, hot-plate and bradykinin-induced flexor reflex tests. Further, in order to search for the sites of analgesic action of ciramadol in rats, the drug was not only administered systemically, but also applied...

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Veröffentlicht in:	Japanese journal of pharmacology 1983-01, Vol.33 (5), p.1085-1088
Hauptverfasser:	KUBOTA, Atsuhiko, SATOH, Masamichi, TAKAGI, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - pharmacology Analgesics Analgesics - pharmacology Animals Benzylamines - pharmacology Biological and medical sciences Bradykinin - pharmacology Dose-Response Relationship, Drug Male Medical sciences Mice Mice, Inbred Strains Naloxone - pharmacology Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Reflex - drug effects Spinal Cord - drug effects
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Zusammenfassung:	Antinociceptive effects of ciramadol were evaluated using three analgesic tests: the tail-pinch, hot-plate and bradykinin-induced flexor reflex tests. Further, in order to search for the sites of analgesic action of ciramadol in rats, the drug was not only administered systemically, but also applied locally to the luinbar subarachnoid space and nuclei reticularis paragigantocellularis and gigantocellularis (NRPG-NRGC), which are sensitive sites to morphine in the production of analgesia.
ISSN:	0021-5198 1347-3506
DOI:	10.1016/S0021-5198(19)52456-8