Bayesian Approach to Bioequivalence Assessment: An Example

□ The statistical methods required for a Bayesian analysis of bioequivalence are outlined and numerically illustrated. The analysis consists of the calculation of the posterior probability, given the experimental results, that the ratio of true means of a new and a standard formulation of a drug wit...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1983-10, Vol.72 (10), p.1178-1181
Hauptverfasser:	Fluehler, H., Grieve, A.P., Mandallaz, D., Mau, J., Moser, H.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	and nomograms Bayes Theorem Bayesian analysis-bioequivalence assessment Bayesian analysis—bioequivalence assessment, statistical methods, example, and nomograms Bioequivalence-assessment by Bayesian analysis Bioequivalence—assessment by Bayesian analysis, statistical methods, example and nomograms Biological and medical sciences Biological Availability Chemistry, Pharmaceutical example example and nomograms General pharmacology Keyphrases Medical sciences Models, Theoretical Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments statistical methods Therapeutic Equivalency
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Beschreibung
Zusammenfassung:	□ The statistical methods required for a Bayesian analysis of bioequivalence are outlined and numerically illustrated. The analysis consists of the calculation of the posterior probability, given the experimental results, that the ratio of true means of a new and a standard formulation of a drug with respect to some biological response lies in a given interval. Nomograms helpful for the calculation of these probabilities are provided.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600721018