Inhibitory effect of ateroid® on rat serum antiplasmin activity

The in vivo fibrinolytic activity of a natural mucopolysaccharide complex (Ateroid®), was demonstrated after intravenous treatment in rabbits: there was an increase in plasmin activity of the euglobulin fraction and a greater effect of small doses of urokinase added in vitro to plasma of treated animals. The studies on the mechanism of action of Ateroid have demonstrated that in the rat, both in vitro and in vivo (administered intraperitoneally or intraduodenally), the drug returns the antiplasmin activity to normal values following experimentally-produced increases in antiplasmin activity by the intravenous injection of Triton® WR 1339 or the oral administration of carbon tetrachloride. The antiplasmin effect is not dependent on the antihyperlipemic activity of Ateroid.