Microbial Transformations of Natural Antitumor Agents XXII: Conversion of Bouvardin to O-Desmethylbouvardin and Bouvardin Catechol

Bouvardin is a cyclic hexapeptide antitumor agent which undergoes two major microbial transformation reactions. Screening with 220 cultures revealed 17 different strains capable of producing O-desmethylbouvardin in good yield. O-Desmethylbouvardin was isolated and characterized from preparative scal...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1983-11, Vol.72 (11), p.1291-1294
Hauptverfasser:	Petroski, Richard J., Bates, Robert B., Linz, Gary S., Rosazza, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - metabolism Aspergillus - metabolism Aspergillus ochraceous Aspergillus ochraceus Biological and medical sciences Biotransformation bouvardin bouvardin catechol Bouvardin-conversion to O-desmethylbouvardin and bouvardin catechol Bouvardin—conversion to O-desmethylbouvardin and bouvardin catechol, microbial transformation, Streptomyces rutgersensis, Aspergillus ochraceous Fermentation General pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Metabolites-bouvardin Metabolites—bouvardin, microbial transformation to O-desmethylbouvardin and bouvardin catechol, Streptomyces rutgersensis, Aspergillus ochraceous microbial transformation microbial transformation to O-desmethylbouvardin and bouvardin catechol Microbial transformation-bouvardin to O-desmethylbouvardin and bouvardin catechol Microbial transformation—bouvardin to O-desmethylbouvardin and bouvardin catechol, Streptomyces rutgersensis, Aspergillus ochraceous O-desmethylbouvardin Peptides, Cyclic - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Streptomyces - metabolism Streptomyces rutgersensis
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Zusammenfassung:	Bouvardin is a cyclic hexapeptide antitumor agent which undergoes two major microbial transformation reactions. Screening with 220 cultures revealed 17 different strains capable of producing O-desmethylbouvardin in good yield. O-Desmethylbouvardin was isolated and characterized from preparative scale incubations with Streptomyces rutgersensis NRRL B-1256. Four aspergilli and one streptomycete formed bouvardin catechol when O-desmethylbouvardin was used as substrate. Bouvardin catechol was isolated and characterized from a preparative scale incubation with Aspergillus ochraceous UI 398.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600721114